GLI3 Is Associated With Neuronal Differentiation in SHH-Activated and WNT-Activated Medulloblastoma

Abstract Glioma-associated oncogene homolog 3 (GLI3), whose main function is to inhibit GLI1, has been associated with neuronal differentiation in medulloblastoma. However, it not clear what molecular subtype(s) show increased GLI3 expression. levels were assessed by immunohistochemistry 2 independent cohorts, including a total of 88 cases, and found be high both WNT- SHH-activated Analysis bulk mRNA expression data single cell RNA sequencing studies confirmed that GLI1 are highly expressed medulloblastoma, whereas but WNT-activated Immunohistochemical analysis shown inside the differentiated nodules GLI1/2 desmoplastic areas. In contrast, diffusely suppressed. Our suggest may master regulator morphology these subgroups.